Hoa Nguyen is a life long learner and who is excited about new science and technique. She received her master’s degree in biochemistry from Vietnam National University. For three years she had been studying the regulation of type-I restriction modification system in Escherichia coli at the Division of Cell and Molecular Biology at the Academy of Sciences of the Czech Republic. She worked in the Nguyen lab for 12 years studying pathogenic mycobacteria and how intrinsic antibiotic resistance and virulence are connected. Her current position in the McDermott lab is comprised of creating transgenic fish to establish a system measuring Ca2+ concentration and the voltage of the membrane in hair cell in zebrafish. In her spare time Hoa loves cooking and writing stories to make her children laugh.

Languages: English, German, Vietnamese.

Email: htn4@case.edu.

Publications:

Guzzo MB, Nguyen HT, Pham TH, Wyszczelska-Rokiel M, Jakubowski H, Wolff KA, , Ogwang S, Timpona JL, Gogula S, Ruetz M, Krauetler B, Jacobs MR, Zhang GF, and Nguyen L. (2016). Methylfolate Trap Promotes Bacterial Thymineless Death By Sulfadrugs. PLOS Pathogens. doi: 10.1371/journal.ppat.1005949[PubMed]

Wolff K, de la Peña AH, Nguyen H, Pham T, Amzel M, Gabelli SB, and Nguyen L. 2015. A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development. PLoS Pathogens. 11(4): e1004839. doi:10.1371/journal.ppat.1004839 [PubMed]

Ogwang S, Nguyen H, Sherman S, Bajaksouzian S, Jacobs MR, Boom WH, Zhang GF, and Nguyen L. (2011) Bacterial conversion of folinic acid is required for antifolate resistance. J Biol Chem. 286: 15377-90. [PubMed]

Nguyen HT, Wolff KA, Cartabuke RH, Ogwang S & Nguyen L. (2010) A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium. Mol Microbiol 76, 348-364. [PubMed]

Wolff KA, Nguyen HT, Cartabuke RH, Singh A, Ogwang S & Nguyen L. (2009) Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. Antimicrob Agents Chemother53, 3515-9. [PubMed]

Nguyen L, Cajthamlova K, Nguyen HT, Weiser J, Holubova I, Weiserova M. ( 2002) Identification of the EcoKI and EcoR124I type I restriction-modification enzyme subunits by non-equilibrium pH gradient two-dimentional gel electrophoresis. Folia Microbiol.(Praha), 47(6): 641-8.